Difference between revisions of "Macromolecular Crystallography"
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* Chayen NE, Boggon TJ, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop SJ, Helliwell JR, Nieh YP, Peterson MR, Raftery J, Snell EH, Hädener A, Niemann AC, Siddons DP, Stojanoff V, Thompson AW, Ursby T, Wulff M [http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=4858924&fileId=S0033583500005837 Trends and Challenges in Experimental Macromolecular Crystallography] ''Quarterly Reviews of Biophysics'' '''1996''', 29 (03), 227-278. [http://dx.doi.org/10.1017/S0033583500005837 doi: 10.1017/S0033583500005837] | * Chayen NE, Boggon TJ, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop SJ, Helliwell JR, Nieh YP, Peterson MR, Raftery J, Snell EH, Hädener A, Niemann AC, Siddons DP, Stojanoff V, Thompson AW, Ursby T, Wulff M [http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=4858924&fileId=S0033583500005837 Trends and Challenges in Experimental Macromolecular Crystallography] ''Quarterly Reviews of Biophysics'' '''1996''', 29 (03), 227-278. [http://dx.doi.org/10.1017/S0033583500005837 doi: 10.1017/S0033583500005837] | ||
* John R. Helliwell and Edward P. Mitchell [http://journals.iucr.org/m/issues/2015/02/00/fs5088/index.html Synchrotron radiation macromolecular crystallography: science and spin-offs] ''IUCrJ'' '''2015''', 2 (2). [http://dx.doi.org/10.1107/S205225251402795X doi: 10.1107/S205225251402795X] | * John R. Helliwell and Edward P. Mitchell [http://journals.iucr.org/m/issues/2015/02/00/fs5088/index.html Synchrotron radiation macromolecular crystallography: science and spin-offs] ''IUCrJ'' '''2015''', 2 (2). [http://dx.doi.org/10.1107/S205225251402795X doi: 10.1107/S205225251402795X] | ||
| − | ===[[ | + | ===[[Serial Femtosecond Crystallography|Serial Crystallography]] using X-ray Free-Electron Lasers ([[XFEL]]s)=== |
* Chapman et al. [http://www.nature.com/nature/journal/v470/n7332/full/nature09750.html Femtosecond X-ray protein nanocrystallography] ''Nature'' '''2011''', 470, 73-77. [http://dx.doi.org/10.1038/nature09750 doi: 10.1038/nature09750] | * Chapman et al. [http://www.nature.com/nature/journal/v470/n7332/full/nature09750.html Femtosecond X-ray protein nanocrystallography] ''Nature'' '''2011''', 470, 73-77. [http://dx.doi.org/10.1038/nature09750 doi: 10.1038/nature09750] | ||
* Ilme Schlichting [http://journals.iucr.org/m/issues/2015/02/00/it5004/index.html Serial femtosecond crystallography: the first five years] ''IUCrJ'' '''2015''', 2 (2). [http://dx.doi.org/10.1107/S205225251402702X doi: 10.1107/S205225251402702X] | * Ilme Schlichting [http://journals.iucr.org/m/issues/2015/02/00/it5004/index.html Serial femtosecond crystallography: the first five years] ''IUCrJ'' '''2015''', 2 (2). [http://dx.doi.org/10.1107/S205225251402702X doi: 10.1107/S205225251402702X] | ||
Revision as of 12:09, 25 August 2015
Macromolecular Crystallography (sometimes abbreviated as MX) is the measurement of single-crystal diffraction patterns, in order to solve for the three-dimensional structure of macromolecules. The sample-of-interest is almost always a protein. Macromolecular crystallography is thus a powerful tool for resolving the three-dimensional structure of proteins, including studying their conformational changes when binding small molecules, or associating with other proteins.
Literature
- Chayen NE, Boggon TJ, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop SJ, Helliwell JR, Nieh YP, Peterson MR, Raftery J, Snell EH, Hädener A, Niemann AC, Siddons DP, Stojanoff V, Thompson AW, Ursby T, Wulff M Trends and Challenges in Experimental Macromolecular Crystallography Quarterly Reviews of Biophysics 1996, 29 (03), 227-278. doi: 10.1017/S0033583500005837
- John R. Helliwell and Edward P. Mitchell Synchrotron radiation macromolecular crystallography: science and spin-offs IUCrJ 2015, 2 (2). doi: 10.1107/S205225251402795X
Serial Crystallography using X-ray Free-Electron Lasers (XFELs)
- Chapman et al. Femtosecond X-ray protein nanocrystallography Nature 2011, 470, 73-77. doi: 10.1038/nature09750
- Ilme Schlichting Serial femtosecond crystallography: the first five years IUCrJ 2015, 2 (2). doi: 10.1107/S205225251402702X
